FEATURES OF GENOMIC AND PHENOTYPIC VARIABILITY OF NEISSERIA GONORRHOEAE SENSITIVITY TO ANTIMICROBIAL DRUGS

Abstract

According to domestic and foreign researchers, gonococcal infection in recent years has been an urgent problem throughout the world, due to the emergence and spread of strains characterized by multiple drug resistance to antimicrobial drugs. The review presents the results of studies on the sensitivity of circulating strains in Kazakhstan and countries of the near and far abroad.

An earlier study of the antibiotic resistance profile of the Kazakh population of Neisseria gonorrhoeae showed that the least active antibiotic against the studied strains of Neisseria gonorrhoeae was penicillin (29.7%), the most active was ceftriaxone (0.7% - resistant and 1.3% - moderately resistant strains). Analysis of the genetic heterogeneity of Kazakh isolates Neisseria gonorrhoeae showed that the 16S-23S ribosomal intergenic spacer of Neisseria gonorrhoeae strains has low intraspecific variability.

Currently, research is ongoing in most countries of the world aimed at studying the ways of spreading antibiotic-resistant strains of gonococci, and molecular mechanisms for the development of resistance, which will allow in the near future to determine the localization and nature of mutations leading to the development of resistance.